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Decort 20 Oily Injection (10ml)

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Description

Decort 20 Oily Injection (10ml)   Injection for sodium and water retention in horses, dogs and cats.

Alters mineral and electrolyte balance; retention of sodium, chloride and water occurs.

Pharmacological properties
Clozantel is a synthetic compound from the group of salicylanides. It inhibits and stops the transfer of electrons, changes the energy metabolism of
parasites and causes their death. It has a wide spectrum of antiparasitic
action, it is active against trematodes, nematodes, mites, lice, sheep’s larva
and larva of gadfly.
After intramuscular injection it is rapidly absorbed, the maximum concentration in the blood is reached in 12 hours and persists for 24-36 hours, and
the therapeutic concentration — for 10-11 days. It is not biotransformed
in the body and is excreted mainly unchanged with feces and in lactating
cows — partly with milk.

Decort 20 Oily Injection (10ml)  Action
Dexamethasone is a synthetic corticosteroid (glucocorticoid). As such, its main actions may be
grouped as follows:
• Anti-inflammatory and Immunological Actions: Glucocorticoids prevent the development of the
inflammatory response, i.e. Redness, swelling, tenderness. They also inhibit capillary dilation and
phagocytosis and appear to prevent the hypersensitivity responses that occur after antigen-antibody
reactions.
• Pharmacological Actions: The principal action of dexamethasone is on gluconeogenesis, glycogen
deposition, and protein and calcium metabolism, together with inhibition of corticotrophin secretion.
Glucocorticoids also influence the mobilization, oxidation, synthesis, and storage of fats. Except for its
use in the treatment of adrenal insufficiency it does not cure disease but it is used rather to treat
disease symptoms because of its pharmacological properties, i.e. Anti-inflammatory and anti-allergic
actions.
Pharmacokinetics
Intramuscular injections of dexamethasone phosphate give maximum plasma concentrations of
dexamethasone at 1 hour. The biological half-life of dexamethasone is about 190 minutes.
In circulation, small amounts of dexamethasone are bound to plasma proteins. Dexamethasone
penetrates into tissue fluids and cerebrospinal fluids. Metabolism of the drug takes place in the
kidney and liver and excretion is via the urine.
Indications
Decort 4 mg ampoule (I.V. or I.M. Injection)
Endocrine Disorders
• Primary or secondary adrenocortical insufficiency (the drug of choice is hydrocortisone or
cortisone – synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in
infancy, mineralocorticoid supplementation is of particular importance).
• Acute adrenocortical insufficiency (the drug of choice is hydrocortisone or cortisone –
mineralocorticoid supplementation may be necessary, particularly when synthetic analogs are used).
• Preoperatively, and in the event of serious trauma or illness in patients with known adrenal
insufficiency, or when adrenocortical reserve is doubtful.
• Shock unresponsive to conventional therapy if adrenocortical insufficiency exists or is suspected.
• Congenital adrenal hyperplasia.
• Nonsuppurative thyroiditis.
• Hypercalcemia associated with cancer.
Rheumatic Disorders
As adjunctive therapy for short-term administration (to tide the patient over an acute episode or
exacerbation) in post-traumatic osteoarthritis, synovitis of osteoarthritis, rheumatoid arthritis
including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy),
acute and subacute bursitis, epicondylitis, acute nonspecific tenosynovitis, acute gouty arthritis,
psoriatic arthritis, ankylosing spondylitis.
Collagen Diseases
During an exacerbation or as maintenance therapy in selected cases of systemic lupus erythematosus
and acute rheumatic carditis.

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